Use of systemic hormonal contraception and depression: a nested case-control study

Introduction Depression is twice as common in women men, especially the young age group. Multiple factors may contribute to this gender difference. Growing attention being focused on role of sex hormones, including those hormonal contraception (HC). Some recent studies have indicated a higher risk depression among using HC, although results are inconclusive. Objectives The aim study examine associations between use and childbearing women. Methods original cohorts for included all aged 15-49 years with at least one redeemed prescriptions HC Finland 2017 (n=294,356), 1:1 age-matched cohort non-users. After exclusion prevalent cases (n=35,102), incident (as recorded Care Register Health Primary Visits) 2018-2019 were identified (n=23,480), 4:1 control group (n=93,920) was selected from above cohorts. Current 180 days before event compared controls, tested via conditional multivariate logistic regression models. Results During follow-up, 23,480 identified. (in event) (OR 0.82, 95% CI 0.79-0.85), particular estradiol- or ethinylestradiol-containing combined associated lower 0.83, 0.76–0.89; OR 0.74, 0.71–0.78, respectively) non-use HC. remained significant 0.87, 0.81-0.95; 0.77, 0.73-0.81, after controlling covariates (marital socioeconomic status, education level, chronic diseases). Use progestin-only not altered depression. Conclusions increased Rather, Disclosure Interest None Declared